Current Research Projects

Drug repurposing targeting Haem oxygenase-1 (HO-1) for prevention of osteosarcoma growth and metastasis

BACKGROUND TO THE RESEARCH PROJECT

The project focuses on understanding and preventing the growth of cancer cells in osteosarcoma patients, as well as looking to stop the spread of cancer around the body. The ability of osteosarcoma to metastasise or spread to different sites is what makes it so aggressive and therefore focusing the research on this is really important. Michael is looking at repurposing a pre-existing drug, which is currently used to treat neonatal jaundice, to block the action of HO-1. HO-1 is a factor which is produced by osteosarcoma patients and prevents the activation of the immune system. By 'kick-starting' the immune system into action, the project will assess if the chemotherapy drugs are able to fight the cancer and stop it from moving to other areas of the body.

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